In line with the decarbonisation of the domestic sector to meet the 2050 climate neutrality targets, this paper describes the energy, economic and environmental analysis of different configurations of polygeneration installations to provide electricity, air conditioning, domestic hot water and desalinated water for a building of 80 dwellings. It will be supplied with renewable energy only, from Photovoltaic (PV) and Photovoltaic-Thermal (PVT) panels, biomass backup boilers, and Thermoelectric Generators (TEG) coupled to the PVTs for additional electricity generation. In the case of cooling and desalinated water production, the use of electrically and thermally activated technologies (Heat Pump, HP/Single-Effect Absorption Chiller, SEAC for cooling, and Multi-effect Distillation, MED/Reverse Osmosis, RO for desalination) will be combined. Electricity can be sold or purchased from the grid without electrical storage with batteries. The four configurations have been simulated for three locations in Spain. They were modeled with TRNSYS, integrating specific models with EES when there was no particular type for desalination technologies. All configurations were designed to cover 100% of the five demands required in the building. For the three locations, the electric option (the combination of HP and RO for cooling and desalting) was the most attractive solution in terms of primary energy consumption and liability. Additionally, they all use a system based on thermal RES.