Brazil is, in its majority, a hot climate country. To promote thermal comfort, several houses, commercial buildings, and public spaces use air conditioning systems, primarily refrigerating systems. However, these machines require a significant amount of energy to operate. As energy is a valuable and limited resource, it must be used strategically and sustainably. Therefore, we have to consume less energy to provide the same outcomes, achieving higher energy efficiency. Consequently is imperative to use the exergy analysis to evaluate these energy conversion systems. For translating the occupants' diversity of bodies and heat production, four types of human thermal models will be used to assess thermal comfort conditions: a man using lighter clothing, a man in traditional office clothing, and two women. We chose these four models since the body composition and basal metabolism rates vary significantly between males and females (in the luteal and follicular phase of the menstrual cycle). In addition, the insulation of garments impacts the thermal comfort conditions. A combination of these four models will represent the occupants of a commercial building. The outputs of these occupants will be used as inputs for a computational model of the building to calculate the associated thermal loads of an actual building in Brazil. A vapor compression system and an absorption system are modeled for this thermal load. Also, the new temperature and humidity setpoints can be explored as options to provide thermal comfort for a more democratic environment with lower energy expenditure and use natural resources more rationally.